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Page 1
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.
Nat Commun. 2021 Sep 3;12(1):5213. doi: 10.1038/s41467-021-25453-2.
Nat Commun. 2021.
PMID: 34480023
Free PMC article.
GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.
Johnston SN, Silagi ES, Madhu V, Nguyen DH, Shapiro IM, Risbud MV.
Johnston SN, et al.
JCI Insight. 2023 Apr 24;8(8):e164883. doi: 10.1172/jci.insight.164883.
JCI Insight. 2023.
PMID: 36917198
Free PMC article.
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Conditional Deletion of HIF-2α in Mouse Nucleus Pulposus Reduces Fibrosis and Provides Mild and Transient Protection From Age-Dependent Structural Changes in Intervertebral Disc.
Johnston SN, Madhu V, Shapiro IM, Risbud MV.
Johnston SN, et al.
J Bone Miner Res. 2022 Dec;37(12):2512-2530. doi: 10.1002/jbmr.4707. Epub 2022 Oct 12.
J Bone Miner Res. 2022.
PMID: 36117450
Free PMC article.
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Increased HIF-2α Activity in the Nucleus Pulposus Causes Intervertebral Disc Degeneration in the Aging Mouse Spine.
Johnston SN, Tsingas M, Ain R, Barve RA, Risbud MV.
Johnston SN, et al.
bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573086. doi: 10.1101/2023.12.22.573086.
bioRxiv. 2023.
PMID: 38187709
Free PMC article.
Updated.
Preprint.
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Increased HIF-2α activity in the nucleus pulposus causes intervertebral disc degeneration in the aging mouse spine.
Johnston SN, Tsingas M, Ain R, Barve RA, Risbud MV.
Johnston SN, et al.
Front Cell Dev Biol. 2024 Mar 6;12:1360376. doi: 10.3389/fcell.2024.1360376. eCollection 2024.
Front Cell Dev Biol. 2024.
PMID: 38510179
Free PMC article.
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